Collagen is the protein of the body’s supporting tissues, and it supports the structures of the skeleton, skin, joints, and other tissues in the body. Collagen is a twisted, fibrous protein with excellent elasticity and tensile strength. The most important role of collagen is to keep the body’s tissues flexible, regenerative, and functional. About 30% of the body’s proteins consist of collagen, and a lack of collagen can weaken the function of joints, bones, and tendons. Collagens are essential in many soft-tissue repair processes in the body.
Osteoarthritis and joint problems affect around 20% of dogs over one year of age. 31% of owners report that bone and joint issues affect their pets. The biggest risk factors for developing osteoarthritis are large size, overweight, genetic factors, or various injuries or traumas. (Mele 2007, Elliott et al. 2007)
Collagen peptides to support cartilage
Bioactive Collagen Peptides® are proven stimulators of articular cartilage metabolism in companion animals. They improve mobility, and they have no side effects. The effects of the Petagile® preparation have been studied in multiple preclinical and clinical studies. When administered orally, these bioactive collagen peptides stimulate chondrocytes to increase the production of new cartilage matrix. The cartilage matrix consists mainly of collagen and proteoglycans, which act as a buffer between bones.
Petagile® – Verified by studies
In several clinical studies involving over 100 dogs, researchers investigated the effects of Petagile® collagen. The results of different studies confirmed Petagile®’s positive outcomes in combating joint problems.
In a study involving 26 German Shepherds, the progression of lameness and mobility difficulties stopped in all dogs that received Petagile® collagen supplementation. In a veterinary examination, 70% of the dogs showed reduced lameness, and their ability to move (getting up, climbing stairs) showed clear improvement in measured parameters after 12 weeks of treatment. The owners’ observations were consistent with the veterinarians’ findings; owners noted improved daily physical activity (walking, climbing stairs, getting up).
Another study was an observational study in medium-sized older dogs, and it included 38 dogs of different breeds, ages, and weights. In the study, 22 dogs were treated with a daily dose of 5 grams of Petagile®, and the second group received a 2.5-gram dose. The study lasted 12 weeks, after which veterinarians evaluated the degree of lameness, pain during movement, posture/comfort at rest, mobility, and swelling in the legs. Blood samples were also taken to analyze extracellular cartilage matrix molecules. The dog owners themselves assessed changes in vitality, stair climbing, and standing.
Support for mobility and quality of life
Based on the data presented, it can be concluded that feeding bioactive collagen peptides has positive effects on canine osteoarthritis, mobility, and maintaining quality of life. The recommended dosage is one gram per five kilograms of body weight. In medium-sized dogs, effects were confirmed at a statistically significant level with a daily dose of 5 grams. Positive effects were also observed with the lower 2.5-gram dosage.
For older dogs, Petagile® can provide increased activity, restore mobility and flexibility, and improve overall wellbeing. For active dogs, it helps support and maintain mobility and flexibility, optimal functional capacity, and performance.
A large share of lameness is caused by osteoarthritis
A large proportion of canine lameness and mobility problems are caused by osteoarthritis. Osteoarthritis is a disease in which joint cartilage is gradually destroyed. This is seen as lameness, pain, and various functional disturbances. A key factor in joint wellbeing is articular cartilage, which is composed of water and different proteins. In addition to cartilage proteins, articular cartilage contains collagen produced by chondrocytes, and this collagen increases the durability of the cartilage. The body needs vitamin C to form collagen.
Petagile® collagen peptides stimulate cartilage tissue metabolism, slow down degradative processes, and accelerate connective tissue growth.
Petagile® helps increase the body’s own collagen production. It also has positive effects in problem areas such as joints and cartilage.
Chia de Gracia’s collagen product is CdG Collagen+, which contains Petagile® collagen, rosehip, MSM, and hyaluronic acid.
PETAGILE® in Dogs - Scientific Substantiation
Study Description:
Application of collagen peptides in dogs with chronic defects of the musculoskeletal system - Germany 2004
Efficacy of orally administered collagen peptides in the treatment of osteoarthritic dogs - Germany 2006
Clinical observational comparison study in medium and large sized dogs of different age 2009
Oral administration of PETAGILE® to dogs with coxarthrose – Observational Study Mexico 2012
Oral administration of PETAGILE® to dogs with coxarthrose – Observational Study Mexico 2014
